ABCG2 p.Asn557Arg
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PMID: 14566825
[PubMed]
Miwa M et al: "Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants."
No.
Sentence
Comment
49
Among PA/ N557X3, PA/N557R expressed little BCRP. Among PA/H630X4 transfectants, moderate BCRP expression was observed in PA/ H630E.
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ABCG2 p.Asn557Arg 14566825:49:21
status: VERIFIED112 Such transfectants include PA/E446D, PA/R486D, PA/R486K, PA/N557R, H630K and H630R.
X
ABCG2 p.Asn557Arg 14566825:112:60
status: VERIFIED
PMID: 15875186
[PubMed]
Mohrmann K et al: "Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2)."
No.
Sentence
Comment
166
However, expression of the mutant BCRP-N557R gave a low expression and the Western blot suggests that only one band was detected instead of the two bands in the other BCRP expressing cells in the same experiment.
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ABCG2 p.Asn557Arg 15875186:166:39
status: VERIFIED167 This suggests that the BCRP-N557R mutant also has a (partial) problem with its folding in the ER.
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ABCG2 p.Asn557Arg 15875186:167:28
status: VERIFIED170 The described difference in resistance of the BCRP-N557H, BCRP-N557D, BCRP-N557E and BCRP-N557R mutants could be partially due to a small difference in folding of BCRP next to a difference in affinity.
X
ABCG2 p.Asn557Arg 15875186:170:90
status: VERIFIED