ABCG2 p.Arg482Ala
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PMID: 14566825
[PubMed]
Miwa M et al: "Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants."
No.
Sentence
Comment
42
Because FACS analysis showed that certain populations of the methotrexate-resistant PA/R482A and PA/R482W cells did not express BCRP (data not shown), all the R482-mutant BCRP transfectants (except R482K-BCRP transfectant) were further selected with 1 ng/ml of mitoxantrone for 5 days to eliminate untransfected cells.
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ABCG2 p.Arg482Ala 14566825:42:87
status: VERIFIED64 PA/R482N, PA/R482C, PA/R482M, PA/R482S, PA/R482T, PA/R482V, PA/R482A, PA/R482G, PA/R482E PA/R482W and PA/R482D (Group 2) showed higher degrees of resistance to mitoxantrone than to SN-38.
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ABCG2 p.Arg482Ala 14566825:64:63
status: VERIFIED163 Group 2 members (PA/R482N, PA/R482C, PA/R482M, PA/R482S, PA/R482T, PA/R482V, PA/ R482A, PA/R482G, PA/R482E PA/R482W and PA/R482D) showed higher degrees of resistance to mitoxantrone than to SN-38.
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ABCG2 p.Arg482Ala 14566825:163:81
status: VERIFIED
PMID: 15517563
[PubMed]
Garcia-Escarp M et al: "Flow cytometry-based approach to ABCG2 function suggests that the transporter differentially handles the influx and efflux of drugs."
No.
Sentence
Comment
117
KB cells transfected with ABCG2-R482A, R482G, and R482T were seeded in the presence of 0.8 M MXR for 1 h at 37°C.
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ABCG2 p.Arg482Ala 15517563:117:32
status: NEW154 Using ABCG2 variant-transfected KB cells, we clearly demonstrated that MXR retention is significantly lower than that observed with wt R482A (MXRA) cells.
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ABCG2 p.Arg482Ala 15517563:154:135
status: NEW
PMID: 20684544
[PubMed]
Morgan J et al: "Substrate Affinity of Photosensitizers Derived from Chlorophyll-a: The ABCG2 Transporter Affects the Phototoxic Response of Side Population Stem Cell-like Cancer Cells to Photodynamic Therapy."
No.
Sentence
Comment
343
A: HEK-293 R482A.
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ABCG2 p.Arg482Ala 20684544:343:11
status: NEW
PMID: 21774076
[PubMed]
Balbuena J et al: "ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties."
No.
Sentence
Comment
109
KB cells transfected with ABCG2- R482A were incubated with 1 lg ml21 Ho342 for 3 h at 378C in the presence or absence of 10 or 30 lM cyclopamine.
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ABCG2 p.Arg482Ala 21774076:109:33
status: NEW