ABCG2 p.Thr82Ala
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PMID: 11807788
[PubMed]
Kage K et al: "Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization."
No.
Sentence
Comment
151
to Ala and Tyr-605 to Cys), HABCRP-37 (Thr-82 to Ala) or HABCRP-74 (Ser-25 to Pro, Arg-309 to Gly and Ala-632 to Val), also expressed mutant BCRP protein, but cells transfected with HABCRP-86 (Lys-86 to Ile) did not express BCRP protein and therefore exhibited no drug resistance.
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ABCG2 p.Thr82Ala 11807788:151:39
status: VERIFIED
PMID: 17027309
[PubMed]
Li YF et al: "Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study."
No.
Sentence
Comment
109
Mutations T82A, K86M, and K86I [42,43] are part of the Walker A motif; all lead to loss of transport activity.
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ABCG2 p.Thr82Ala 17027309:109:10
status: VERIFIED110 The T82A mutation results in the possible loss of interaction with residue R193 in the neighboring LSGGQ motif, potentially affecting dimer assembly.
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ABCG2 p.Thr82Ala 17027309:110:4
status: VERIFIED