ABCG2 p.Ala632Val
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PMID: 11807788
[PubMed]
Kage K et al: "Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization."
No.
Sentence
Comment
151
to Ala and Tyr-605 to Cys), HABCRP-37 (Thr-82 to Ala) or HABCRP-74 (Ser-25 to Pro, Arg-309 to Gly and Ala-632 to Val), also expressed mutant BCRP protein, but cells transfected with HABCRP-86 (Lys-86 to Ile) did not express BCRP protein and therefore exhibited no drug resistance.
X
ABCG2 p.Ala632Val 11807788:151:102
status: VERIFIED
PMID: 15209530
[PubMed]
Stefkova J et al: "ATP-binding cassette (ABC) transporters in human metabolism and diseases."
No.
Sentence
Comment
106
The substitution of valine for alanine at amino acid 632 was associated with plasma cholesterol concentrations, but was not consistently associated with any of the other sterols.
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ABCG2 p.Ala632Val 15209530:106:20
status: NEW
PMID: 22693078
[PubMed]
Gyimesi G et al: "ABCMdb: A database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application."
No.
Sentence
Comment
138
There were two cases where the reverse of the mutation was mentioned in the reference paper, such as "A632V" instead of "V632A" (p.Val632Ala), which might indicate a sequence ambiguity.
X
ABCG2 p.Ala632Val 22693078:138:102
status: NEW