ABCC8 p.Lys205Glu
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PMID: 22802363
[PubMed]
Pratt EB et al: "Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels."
No.
Sentence
Comment
102
Error bars represent SEM, and some are smaller than the symbols. (K199E, R202E, E203K, and K205E) and then coexpressed with WT-, Q52E-, or Q52R-Kir6.2.
X
ABCC8 p.Lys205Glu 22802363:102:93
status: NEW104 When coexpressed with WTKir6.2, only K205E-SUR1 had an obvious effect on ATP sensitivity, causing reduced inhibition by ATP (hereinafter "//" is used to denote heteromeric Kir6.2 and SUR1 combinations and "/" is used to separate multiple mutations in a single SUR1 or Kir6.2 subunit).
X
ABCC8 p.Lys205Glu 22802363:104:37
status: NEW107 Combination of K205E-SUR1 and Q52E-Kir6.2 yielded channels with decreased ATP sensitivity close to that seen in WT-Kir6//K205E-SUR1 channels.
X
ABCC8 p.Lys205Glu 22802363:107:15
status: NEWX
ABCC8 p.Lys205Glu 22802363:107:121
status: NEW117 Only 1 mM ATP was tested in the cases of E203K-SUR1// Q52R-Kir6.2 and K205E-SUR1// Q52R-Kir6.2 because of extremely low ATP sensitivity.
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ABCC8 p.Lys205Glu 22802363:117:70
status: NEW