ABCC7 p.Tyr275Leu
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PMID: 26496611
[PubMed]
Sorum B et al: "Timing of CFTR Pore Opening and Structure of Its Transition State."
No.
Sentence
Comment
63
Timing of Motion at Position 275 of the NBD2-TMD Interface (A) Inward single-channel currents of the cut-DR(D1370N) CFTR background construct (top trace) and of channels bearing mutations Y275F, Y275E, Y275K, Y275L, and Y275S, respectively, in the same background. Currents were recorded at 80 mV, in symmetrical 140 mM Cl ; dashes on the left mark zero-current level.
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ABCC7 p.Tyr275Leu 26496611:63:209
status: NEW96 Kinetic analysis revealed a clear tendency for opposing effects on channel closing and opening rates, both contributing about equally to changes in Po: lengthened tb was mostly associated with shortened tib and (in Y275L) shortened tb with lengthened tib (Figures 3B and 3C).
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ABCC7 p.Tyr275Leu 26496611:96:215
status: NEW