ABCC7 p.Arg487Ser
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PMID: 26149808
[PubMed]
Chong PA et al: "Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization."
No.
Sentence
Comment
244
To determine whether we were observing intermolecular interactions between Arg-487 and Asp-565 and Asp-567, which form the di-acidic motif, we introduced the R487S mutation to remove the positive charge and disrupt this interface.
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ABCC7 p.Arg487Ser 26149808:244:158
status: NEW245 R487S NBD1 èc;RIèc;RE still exhibits FIGURE 7. a, mapping of the concentration-dependent chemical shift perturbations for NBD1 on a ribbon diagram of NBD1 using spheres colored according to the legend.
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ABCC7 p.Arg487Ser 26149808:245:0
status: NEW